MALPEZZI, GIULIA
MALPEZZI, GIULIA
Dipartimento di Scienze Biomediche, Metaboliche e Neuroscienze
A toolbox of biophysical and analytical assays helps to confirm the activity of novel hTS dimer disrupters (Ddis) with anticancer properties
2022 Tagliazucchi, Lorenzo; Venturelli, Alberto; Malpezzi, Giulia; Moschella, MARIA GAETANA; Aiello, Daniele; Lopresti, Ludovica; Pozzi, Cecilia; Marverti, Gaetano; D'Arca, Domenico; Ponterini, Glauco; Costi, Maria Paola
Advancing sustainable drug development: comparative preclinical study of H80 and Miltefosine using imaging and proteomics
2024 Malpezzi, Giulia; Di Persio, Sara; Tagliazucchi, Lorenzo; Aiello, Daniele; Venturelli, Alberto; Cordeiro-da-Silva, Anabela; Santarem, Nuno; Ponterini, Glauco; Costi, Maria Paola
Applying optical tweezers technology to reveal Thymidylate Synthase interactions with its consensus mRNA
2023 Malpezzi, Giulia; Viader, Xvaier; Zaltron, Annamaria; Neri, Benedetta; Di Felice, Giulia; Tagliazucchi, Lorenzo; Aiello, Daniele; Moschella, Maria Gaetana; Costi, Maria Paola; D’Arca, Domenico; Cecconi, Ciro
Current Treatments to Control African Trypanosomiasis and One Health Perspective
2022 Venturelli, Alberto; Tagliazucchi, Lorenzo; Lima, Clara; Venuti, Federica; Malpezzi, Giulia; Magoulas, George E.; Santarem, Nuno; Calogeropoulou, Theodora; Cordeiro-da-Silva, Anabela; Costi, Maria Paola
Deciphering Host–Parasite Interplay in Leishmania Infection through a One Health View of Proteomics Studies on Drug Resistance
2024 Tagliazucchi, Lorenzo; Pinetti, Diego; Genovese, Filippo; Malpezzi, Giulia; Perea Martinez, Ana; Manzano, José I.; García-Hernández, Raquel; Cole, Alexander R.; Kwon, Ba Reum; Aiello, Daniele; Brooks, Bryan W.; Thoré, Eli S. J.; Bertram, Michael G.; Gamarro, Francisco; Costi, Maria Paola
design, synthesis and biological evaluation of novel YAP:TEAD complex disruptors for thetreatment of colorectal cancer
2023 Tagliazucchi, Lorenzo; Venturelli, Alberto; Malpezzi, Giulia; Zappaterra, Dana; Aiello, Daniele; Elisi, Gian Marco; Mor, Marco; Moschella, Maria Gaetana; Marverti, Gaetano; D'Arca, Domenico; Ponterini, Glauco; Costi, Maria Paola
Designing selective Cys-ligands to unpair the binding of the Human Transcription Enhancer Associated Domain 4 (hTEAD-4) with its modulators to halt cancer cell growth
2021 Tagliazucchi, Lorenzo; Malpezzi, Giulia; Pozzi, Cecilia; Lopresti, Ludovica; Venturelli, Alberto; D'Arca, Domenico; Marverti, Gaetano; Cecconi, Ciro; Ponterini, Glauco; Costi, Maria Paola
Development of a fluorescent anisotropy displacement assay for the optimization of YAP:TEAD molecular disrupters with anticancer activity
2024 Malpezzi, Giulia; Elisi, Gianmarco; Scalvini, Laura; Tagliazucchi, Lorenzo; Aiello, Daniele; Guerrini, Remo; D’Arca, Domenico; Marverti, Gaetano; Pozzi, Cecilia; Venturelli, Alberto; Ponterini, Glauco; Mor, Marco; Costi, Maria Paola
Development of a novel class of YAP:TEAD interface-3 molecular disruptors to treat colorectal carcinoma
2023 Tagliazucchi, Lorenzo; Malpezzi, Giulia; Aiello, Daniele; Zappaterra, Dana; Elisi, Gian Marco; Venturelli, Alberto; Moschella, Maria Gaetana; D’Arca, Domenico; Marverti, Gaetano; Lopresti, Ludovica; Pozzi, Cecilia; Pacifico, Salvatore; Guerrini, Remo; Ponterini, Glauco; Costi, Maria Paola
Drug discovery of pyrazolo-piperidinone inhibitors targeting YAP:TEAD interaction and development of a fluorescence anisotropy assay for high-throughput screening
2025 Malpezzi, Giulia; Scalvini, Laura; Tagliazucchi, Lorenzo; Chiaravalle, Annalisa; Aiello, Daniele; Saporito, Giulia; Illuminati, Davide; Pacifico, Salvatore; Guerrini, Remo; Pozzi, Cecilia; Venturelli, Alberto; Ponterini, Glauco; Mor Sheraz Gul, Marco; Costi, Maria Paola
Exploiting Forster Resonance Energy Transfer (FRET) in the characterization of YAP:TEAD complex disruption
2022 Tagliazucchi, Lorenzo; Rossi, Marianna; Malpezzi, Giulia; Zappaterra, Dana; Aiello, Daniele; Pozzi, Cecilia; Pacifico, Salvatore; Guerrini, Remo; Venturelli, Alberto; Ponterini, Glauco; Costi, Maria Paola
Exploiting the Optical Tweezer technology to reveal thymidylate synthase interactions with its consensus mRNA
2023 Malpezzi, Giulia; Viander, Xavier; Zaltron, Annamaria; Neri, Benedetta; Di Felice, Giulia; Tagliazucchi, Lorenzo; Aiello, Daniele; Moschella, MARIA GAETANA; Costi, Maria Paola; D'Arca, Domenico; Cecconi, Ciro
EXPLOITING THE OPTICAL TWEEZER, A SINGLE MOLECULE TECHNOLOGY, TO REVEAL THYMIDYLATE SYNTHASE INTERACTIONS WITH ITS CONSENSUS mRNA
2023 Malpezzi, Giulia; Viander, Xavier; Zaltron, Annamaria; Neri, Benedetta; Di Felice, Giulia; Tagliazucchi, Lorenzo; Aiello, Daniele; Moschella, Maria; Costi, Maria Paola; D’Arcae, Domenico; Cecconi, Ciro
Exploring thymidylate synthase mRNA binding site 1 and human TS protein interaction with optical tweezers and bicistronic expression assay
2024 Malpezzi, Giulia; Viander, Xavier; Zaltron, Annamaria; Tagliazucchi, Lorenzo; Aiello, Daniele; D’Arca, Domenico; Cecconi, Ciro; Costi, Maria Paola
IDENTIFICATION OF PYRAZOLO-PIPERIDINONE DERIVATIVES TARGETING YAP-TEAD INTERFACE 3 AS ANTICANCER AGENTS THROUGH INTEGRATED VIRTUAL SCREENING AND MASS SPECTROMETRY PROTEOMICS
2025 Scalvini, Laura; Tagliazucchi, Lorenzo; Elisi, Gian Marco; Zappaterra, Dana; Moschella, Maria Gaetana; Fantini, Sebastian; Aiello, Daniele; Guerrini, Remo; Albanese, Valentina; Pacifico, Salvatore; Lopresti, Ludovica; Malpezzi, Giulia; Saporito, Giulia; Ferrari, Stefania; Lamesta, Michele; Losi, Lorena; Pozzi, Cecilia; Mangani, Stefano; Marverti, Gaetano; Venturelli, Alberto; Ponterini, Glauco; D'Arca, Domenico; Mor, Marco; Costi, Maria Paola
Insights into host-target interaction from the proteome modulation analysis through untargeted LC-MS/MS Proteomics of drug resistant L infantum-THP1 infected cells
2023 Tagliazucchi, Lorenzo; Malpezzi, Giulia; Perea Martinez, Ana; Ignacio Manzano, José; Garcia-Hernandez, Raquel; Pinetti, Diego; Genovese, Filippo; Thorè, Eli; Brooks, Bryan W.; Bertram, Michael G.; Gamarro, Francisco; Costi, Maria Paola
Intersite Communication in Dimeric Enzymes Highlighted by Structural and Thermodynamic Analysis of Didansyltyrosine Binding to Thymidylate Synthases
2024 Venturelli, Alberto; Guaitoli, Giambattista; Vanossi, Davide; Saitta, Francesca; Fessas, Dimitrios; Vitiello, Simone; Malpezzi, Giulia; Aiello, Daniele; Ferrari, Stefania; Tondi, Donatella; Ponterini, Glauco; Costi, Maria Paola
Investigating the mechanism of action of the antiparasitic agent H80 through imaging techniques
2023 Malpezzi, Giulia; Tagliazucchi, Lorenzo; Aiello, Daniele; Venturelli, Alberto; Cordeiro-da-Silva, Anabela; Santarem, Nuno; Ponterini, Glauco; Costi, Maria Paola
LC-MS/MS proteomics for the rapid and selective screening of drug resistances in Leishmania infantum clinical isolates
2023 Tagliazucchi, Lorenzo; Malpezzi, Giulia; Perea Martinez, Ana; Ignacio Manzano, José; Garcia-Hernandez, Raquel; Pinetti, Diego; Genovese, Filippo; Costi, Maria Paola
Lead optimization of human thymidylate synthase dimer disrupters: from computational studies to evaluation of their biological profiles
2023 Aiello, Daniele; Malpezzi, Giulia; Tagliazucchi, Lorenzo; Moschella, Maria Gaetana; Saporito, Giulia; Venturelli, Alberto; Ponterini, Gluaco; D’Arca, Domenico; Marverti, Gaetano; Falchi, Federico; Costi, Maria Paola
| Titolo | Data di pubblicazione | Autore(i) | File |
|---|---|---|---|
| A toolbox of biophysical and analytical assays helps to confirm the activity of novel hTS dimer disrupters (Ddis) with anticancer properties | 1-gen-2022 | Tagliazucchi, Lorenzo; Venturelli, Alberto; Malpezzi, Giulia; Moschella, MARIA GAETANA; Aiello, Daniele; Lopresti, Ludovica; Pozzi, Cecilia; Marverti, Gaetano; D'Arca, Domenico; Ponterini, Glauco; Costi, Maria Paola | |
| Advancing sustainable drug development: comparative preclinical study of H80 and Miltefosine using imaging and proteomics | 1-gen-2024 | Malpezzi, Giulia; Di Persio, Sara; Tagliazucchi, Lorenzo; Aiello, Daniele; Venturelli, Alberto; Cordeiro-da-Silva, Anabela; Santarem, Nuno; Ponterini, Glauco; Costi, Maria Paola | |
| Applying optical tweezers technology to reveal Thymidylate Synthase interactions with its consensus mRNA | 1-gen-2023 | Malpezzi, Giulia; Viader, Xvaier; Zaltron, Annamaria; Neri, Benedetta; Di Felice, Giulia; Tagliazucchi, Lorenzo; Aiello, Daniele; Moschella, Maria Gaetana; Costi, Maria Paola; D’Arca, Domenico; Cecconi, Ciro | |
| Current Treatments to Control African Trypanosomiasis and One Health Perspective | 1-gen-2022 | Venturelli, Alberto; Tagliazucchi, Lorenzo; Lima, Clara; Venuti, Federica; Malpezzi, Giulia; Magoulas, George E.; Santarem, Nuno; Calogeropoulou, Theodora; Cordeiro-da-Silva, Anabela; Costi, Maria Paola | |
| Deciphering Host–Parasite Interplay in Leishmania Infection through a One Health View of Proteomics Studies on Drug Resistance | 1-gen-2024 | Tagliazucchi, Lorenzo; Pinetti, Diego; Genovese, Filippo; Malpezzi, Giulia; Perea Martinez, Ana; Manzano, José I.; García-Hernández, Raquel; Cole, Alexander R.; Kwon, Ba Reum; Aiello, Daniele; Brooks, Bryan W.; Thoré, Eli S. J.; Bertram, Michael G.; Gamarro, Francisco; Costi, Maria Paola | |
| design, synthesis and biological evaluation of novel YAP:TEAD complex disruptors for thetreatment of colorectal cancer | 1-gen-2023 | Tagliazucchi, Lorenzo; Venturelli, Alberto; Malpezzi, Giulia; Zappaterra, Dana; Aiello, Daniele; Elisi, Gian Marco; Mor, Marco; Moschella, Maria Gaetana; Marverti, Gaetano; D'Arca, Domenico; Ponterini, Glauco; Costi, Maria Paola | |
| Designing selective Cys-ligands to unpair the binding of the Human Transcription Enhancer Associated Domain 4 (hTEAD-4) with its modulators to halt cancer cell growth | 1-gen-2021 | Tagliazucchi, Lorenzo; Malpezzi, Giulia; Pozzi, Cecilia; Lopresti, Ludovica; Venturelli, Alberto; D'Arca, Domenico; Marverti, Gaetano; Cecconi, Ciro; Ponterini, Glauco; Costi, Maria Paola | |
| Development of a fluorescent anisotropy displacement assay for the optimization of YAP:TEAD molecular disrupters with anticancer activity | 1-gen-2024 | Malpezzi, Giulia; Elisi, Gianmarco; Scalvini, Laura; Tagliazucchi, Lorenzo; Aiello, Daniele; Guerrini, Remo; D’Arca, Domenico; Marverti, Gaetano; Pozzi, Cecilia; Venturelli, Alberto; Ponterini, Glauco; Mor, Marco; Costi, Maria Paola | |
| Development of a novel class of YAP:TEAD interface-3 molecular disruptors to treat colorectal carcinoma | 1-gen-2023 | Tagliazucchi, Lorenzo; Malpezzi, Giulia; Aiello, Daniele; Zappaterra, Dana; Elisi, Gian Marco; Venturelli, Alberto; Moschella, Maria Gaetana; D’Arca, Domenico; Marverti, Gaetano; Lopresti, Ludovica; Pozzi, Cecilia; Pacifico, Salvatore; Guerrini, Remo; Ponterini, Glauco; Costi, Maria Paola | |
| Drug discovery of pyrazolo-piperidinone inhibitors targeting YAP:TEAD interaction and development of a fluorescence anisotropy assay for high-throughput screening | 1-gen-2025 | Malpezzi, Giulia; Scalvini, Laura; Tagliazucchi, Lorenzo; Chiaravalle, Annalisa; Aiello, Daniele; Saporito, Giulia; Illuminati, Davide; Pacifico, Salvatore; Guerrini, Remo; Pozzi, Cecilia; Venturelli, Alberto; Ponterini, Glauco; Mor Sheraz Gul, Marco; Costi, Maria Paola | |
| Exploiting Forster Resonance Energy Transfer (FRET) in the characterization of YAP:TEAD complex disruption | 1-gen-2022 | Tagliazucchi, Lorenzo; Rossi, Marianna; Malpezzi, Giulia; Zappaterra, Dana; Aiello, Daniele; Pozzi, Cecilia; Pacifico, Salvatore; Guerrini, Remo; Venturelli, Alberto; Ponterini, Glauco; Costi, Maria Paola | |
| Exploiting the Optical Tweezer technology to reveal thymidylate synthase interactions with its consensus mRNA | 1-gen-2023 | Malpezzi, Giulia; Viander, Xavier; Zaltron, Annamaria; Neri, Benedetta; Di Felice, Giulia; Tagliazucchi, Lorenzo; Aiello, Daniele; Moschella, MARIA GAETANA; Costi, Maria Paola; D'Arca, Domenico; Cecconi, Ciro | |
| EXPLOITING THE OPTICAL TWEEZER, A SINGLE MOLECULE TECHNOLOGY, TO REVEAL THYMIDYLATE SYNTHASE INTERACTIONS WITH ITS CONSENSUS mRNA | 1-gen-2023 | Malpezzi, Giulia; Viander, Xavier; Zaltron, Annamaria; Neri, Benedetta; Di Felice, Giulia; Tagliazucchi, Lorenzo; Aiello, Daniele; Moschella, Maria; Costi, Maria Paola; D’Arcae, Domenico; Cecconi, Ciro | |
| Exploring thymidylate synthase mRNA binding site 1 and human TS protein interaction with optical tweezers and bicistronic expression assay | 1-gen-2024 | Malpezzi, Giulia; Viander, Xavier; Zaltron, Annamaria; Tagliazucchi, Lorenzo; Aiello, Daniele; D’Arca, Domenico; Cecconi, Ciro; Costi, Maria Paola | |
| IDENTIFICATION OF PYRAZOLO-PIPERIDINONE DERIVATIVES TARGETING YAP-TEAD INTERFACE 3 AS ANTICANCER AGENTS THROUGH INTEGRATED VIRTUAL SCREENING AND MASS SPECTROMETRY PROTEOMICS | 1-gen-2025 | Scalvini, Laura; Tagliazucchi, Lorenzo; Elisi, Gian Marco; Zappaterra, Dana; Moschella, Maria Gaetana; Fantini, Sebastian; Aiello, Daniele; Guerrini, Remo; Albanese, Valentina; Pacifico, Salvatore; Lopresti, Ludovica; Malpezzi, Giulia; Saporito, Giulia; Ferrari, Stefania; Lamesta, Michele; Losi, Lorena; Pozzi, Cecilia; Mangani, Stefano; Marverti, Gaetano; Venturelli, Alberto; Ponterini, Glauco; D'Arca, Domenico; Mor, Marco; Costi, Maria Paola | |
| Insights into host-target interaction from the proteome modulation analysis through untargeted LC-MS/MS Proteomics of drug resistant L infantum-THP1 infected cells | 1-gen-2023 | Tagliazucchi, Lorenzo; Malpezzi, Giulia; Perea Martinez, Ana; Ignacio Manzano, José; Garcia-Hernandez, Raquel; Pinetti, Diego; Genovese, Filippo; Thorè, Eli; Brooks, Bryan W.; Bertram, Michael G.; Gamarro, Francisco; Costi, Maria Paola | |
| Intersite Communication in Dimeric Enzymes Highlighted by Structural and Thermodynamic Analysis of Didansyltyrosine Binding to Thymidylate Synthases | 1-gen-2024 | Venturelli, Alberto; Guaitoli, Giambattista; Vanossi, Davide; Saitta, Francesca; Fessas, Dimitrios; Vitiello, Simone; Malpezzi, Giulia; Aiello, Daniele; Ferrari, Stefania; Tondi, Donatella; Ponterini, Glauco; Costi, Maria Paola | |
| Investigating the mechanism of action of the antiparasitic agent H80 through imaging techniques | 1-gen-2023 | Malpezzi, Giulia; Tagliazucchi, Lorenzo; Aiello, Daniele; Venturelli, Alberto; Cordeiro-da-Silva, Anabela; Santarem, Nuno; Ponterini, Glauco; Costi, Maria Paola | |
| LC-MS/MS proteomics for the rapid and selective screening of drug resistances in Leishmania infantum clinical isolates | 1-gen-2023 | Tagliazucchi, Lorenzo; Malpezzi, Giulia; Perea Martinez, Ana; Ignacio Manzano, José; Garcia-Hernandez, Raquel; Pinetti, Diego; Genovese, Filippo; Costi, Maria Paola | |
| Lead optimization of human thymidylate synthase dimer disrupters: from computational studies to evaluation of their biological profiles | 1-gen-2023 | Aiello, Daniele; Malpezzi, Giulia; Tagliazucchi, Lorenzo; Moschella, Maria Gaetana; Saporito, Giulia; Venturelli, Alberto; Ponterini, Gluaco; D’Arca, Domenico; Marverti, Gaetano; Falchi, Federico; Costi, Maria Paola |
